Gold and penicillamine

Pulmonary damage with gold or penicillamine.

HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.

Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR ...

Gold and penicillamine: a proposed mode of action in rheumatoid arthritis, based on synovial fluid analysis.

Although in common use, there is still controversy as to the way in which gold and penicillamine act in rheumatoid arthritis (RA). In this study, synovial fluids from 4 groups of patients have been compared: (1) RA patients on gold/penicillamine, (2) RA patients on non-steriodal anti-inflammatory drugs (NSAID) only, (3) osteoarthritis patients, and (4) patients with sero-negative arthropathies....

Trial comparing D-penicillamine and gold in rheumatoid arthritis. Preliminary report.

The Multicentre Trial Group (1973) showed that penicillamine was superior to placebo in a doubleblind trial against placebo. In this trial penicillamine was compared with gold. There are three reasons why a double-blind trial of penicillamine and gold was not attempted; first, gold is given by injection and penicillamine orally;. secondly, both drugs have distinctive side effects which might 'u...

Relationship of gold and penicillamine therapy to diffuse interstitial lung disease.

Seven cases of diffuse interstitial lung disease (DILD) are reported with an unequivocal temporal relationship between the development of the lung disease and treatment with gold (6 cases) and penicillamine (1 case). They were characterised clinically by the sudden onset of dyspnoea and crepitations and radiologically by diffuse bilateral pulmonary shadowing. Most showed evidence of hypersensit...